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Basic Facts about NUT Midline Carcinoma

Pathology

Treatment

Recommendations

Consultations

Registry Personnel


Treatment

The treatment of NUT midline carcinoma often includes surgery, radiation therapy, and chemotherapy. No single approach may be advocated for all patients. When feasible, complete surgical resection has been associated with improved outcomes. However, since the disease is often locally advanced and/or distantly metastatic at initial presentation, complete resection often cannot be safely performed. A variety of radiation therapy and chemotherapy modalities have been used. These have included combination standard cytotoxic regimens applied in other carcinomas, sarcomas, germ cell tumors, and other solid tumors. Unfortunately no clearly superior regimen has emerged. Not uncommonly an initial response to therapy is observed. However the disease typically recurs rapidly in a treatment-refractory manner. Due to the rarity of the disease, its varied clinical manifestations, and the non-uniform treatments administered, it has been challenging to evaluate the efficacy of various therapeutic approaches. One goal of this Registry is to collect clinical data regarding response to various treatments and to share this information with the medical community. Registry staff are available to provide consultation on an individual case basis.




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